Principal Investigator

​​​​​​​​Seema Aceves, MD-PhD​

​What We Do​

The Aceves Lab conducts clinical and translational investigations of the impact and mechanisms of tissue remodeling on eosinophilic esophagitis (EOE). A disease of increasing worldwide prevalence, EoE is quickly becoming ​​​​​​​​a significant healthcare burden. The Aceves Lab uses primary human esophageal cells and tissue as in vitro model systems to understand the mechanisms driving epithelial, fibroblast, and smooth muscle changes in EoE​​​​

​​Facilities​​​

​​Biomedical Research Facil​ity II

​Rady C​hildren's Hospital Acute Care Pavillion



Research Highlights

​FDA APPROVES TAKEDA'S EOHILIA (BUDESONIDE ORAL SUSPENSION), THE FIRST AND ONLY ORAL TREATMENT IN THE U.S. FOR EOSINOPHILIC ESOPHAGITIS (EOE)!



Increased Production of LIGHT by T Cells in Eosinophilic Esophagitis Promotes Differentiation of Esophageal Fibroblasts Toward an Inflammatory Phenotype, Gastroenterology 2020

A Newly Proposed​ Severity Index for Eosinophilic Esophagitis is Associated with Baseline Clinical Features and Successful Treatment Response


Clinical Guidance for the Use of Dupilumab in ​Eosinophilic Esophagitis: A Yardstick

​A Deficiency in the Cytokine TNFSF14/LIGHT Limits Inflammation and Remodeling in Murine Eosinophilic Esophagitis​​


​​Curre​nt Clinical Research Studies​​

Characteristic and inflammatory markers in children with Eosinophilic Esophagitis (EoE): a prospective study

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​​​A Prospective Multicenter Study to Compare and Validate Endoscopic, Histologic, Molecular, and Patient-Reported Outcomes in Pediatric and Adult Patients with Eosinophilic Esophagitis (EoE), Gastiris (EoG), Enteritis (EoN) and Colitis (EoC)


Tracking the effects of IL-4 and IL-13 on T cells by lineage tracing


Somatization, Anxiety, and Disordered Sleep in Pediatric Eosinophilic Esophagitis​​

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Our Support Comes From

 

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​Get In Tou​​ch

​​​University of California San Diego

School of Medicine

Biomedical Research Facility II

9500 Gilman Drive, La Jolla, CA 92093

MC0760


Lab:

858.534.1860


Clinic: 

858.966.5961​


Clinical Research: 858.966.6884